Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.55 |
| ▸ | HRH2 | P25021 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | SLC47A1 | Q96FL8 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ATP4A | P20648 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | ATP4B | P51164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10781928 | 0.88 | ACHE (0.72) | ACHEHRH2LMNATSHRSLC47A1 | |
| SCHEMBL10975569 | 0.86 | ACHE (0.56) | ACHEHRH2LMNATSHRSLC47A1 | |
| Bromide SCHEMBL8944149 | 0.82 | ACHE (0.63) | ACHEHRH2LMNATSHRSLC47A1 | |
| SCHEMBL10781775 | 0.82 | ACHE (0.66) | ACHEHRH2LMNATSHRSLC47A1 | |
| SCHEMBL10975605 | 0.82 | ACHE (0.54) | ACHEHRH2LMNATSHRSLC47A1 | |
| Iodide SCHEMBL8743624 | 0.81 | ACHE (0.76) | ACHEHRH2LMNATSHRSLC47A1 | |
| Hydrochloric Acid SCHEMBL8743619 | 0.81 | ACHE (0.76) | ACHEHRH2LMNATSHRSLC47A1 | |
| Bromide SCHEMBL8943997 | 0.81 | ACHE (0.76) | ACHEHRH2LMNATSHRSLC47A1 | |
| SCHEMBL10781025 | 0.81 | ACHE (0.54) | ACHEHRH2LMNATSHRSLC47A1 | |
| SCHEMBL10426666 | 0.78 | ACHE (0.60) | ACHEHRH2LMNATSHRSLC47A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091220-B1 | THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4474794-A | N-Thiazolylmethylthioalkyl-N1 -alkenyl (or alkynyl)guanidines and related compounds | ELI LILLY AND COMPANY (US) | 1984-10-02 | — | — | US | disclosed |
| EP-0091220-A2 | Thiazole derivatives, process for their preparation and pharmaceutical compositions containing them | ELI LILLY AND COMPANY (US) | 1983-10-12 | — | — | EP | disclosed |