Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 14/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 8/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | CASP6 | P55212 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 10/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10662416 | 0.89 | ADRB2 (0.52) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10662496 | 0.89 | ADRB2 (0.52) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10657723 | 0.86 | ADRB3 (0.63) | ADRB3ADRB2 | |
| SCHEMBL10662739 | 0.84 | ADRB3 (0.54) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL4389552 | 0.82 | ADRB2 (0.54) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL4389556 | 0.82 | ADRB2 (0.54) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10658750 | 0.82 | ADRB2 (0.50) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10661432 | 0.82 | ADRB2 (0.49) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10661230 | 0.80 | ADRB2 (0.58) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL11875004 | 0.78 | ADRB2 (0.58) | ADRB3ADRB2CASP3CASP6ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4654371-A | ANTI-OBESITY, HYPOGLYCEMIA AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-31 | — | — | US | disclosed |
| US-4478849-A | HYPERGLYCEMIC AGENTS | BEECHAM GROUP LIMITED (GB) | 1984-10-23 | — | — | US | disclosed |
| EP-0006735-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1983-06-15 | — | — | EP | disclosed |
| EP-0006735-A1 | Secondary amines, their preparation, pharmaceutical compositions containing them and their use | BEECHAM GROUP PLC (GB) | 1980-01-09 | — | — | EP | disclosed |