Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 9/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 14/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | CASP6 | P55212 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 11/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11873887 | 0.89 | ADRB2 (0.60) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10662533 | 0.88 | ADRB2 (0.63) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10661718 | 0.88 | ADRB2 (0.63) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL9664001 | 0.88 | ADRB2 (0.63) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL11875004 | 0.86 | ADRB2 (0.58) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL11874205 | 0.86 | ADRB2 (0.54) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10664103 | 0.85 | ADRB2 (0.69) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10658794 | 0.84 | ADRB3 (0.75) | ADRB3ADRB2 | |
| SCHEMBL10786212 | 0.84 | ADRB3 (0.50) | ADRB3ADRB2CASP3CASP6ADRB1 | |
| SCHEMBL10663303 | 0.83 | ADRB2 (0.58) | ADRB3ADRB2CASP3CASP6ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4753962-A | HYPOGLYCEMIC, ANTIOBESITY AGENT | BEECHAM GROUP P.L.C. (GB) | 1988-06-28 | — | — | US | disclosed |
| US-4654371-A | ANTI-OBESITY, HYPOGLYCEMIA AGENTS | BEECHAM GROUP P.L.C. (GB) | 1987-03-31 | — | — | US | disclosed |
| EP-0006735-B1 | SECONDARY AMINES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | BEECHAM GROUP PLC (GB) | 1983-06-15 | — | — | EP | disclosed |