Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 10/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | CDC7 | O00311 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | PAK4 | O96013 | 1/20 | 0.45 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078876 | 0.83 | ALK (0.48) | ZAP70ALKMAPK1INSRCDC7 | |
| SCHEMBL6151150 | 0.80 | ZAP70 (0.65) | ZAP70ALKNTRK1IGF1RPTK2 | |
| SCHEMBL375534 | 0.80 | ZAP70 (0.65) | PRKCQZAP70ALKMAPK1INSR | |
| SCHEMBL5291249 | 0.76 | ALK (0.48) | ZAP70ALKMAPK1INSRCDC7 | |
| SCHEMBL5284485 | 0.74 | ZAP70 (0.45) | ZAP70ALKMAPK1INSRCDC7 | |
| SCHEMBL14735828 | 0.71 | ALK (0.53) | ALKINSRJAK2METSRC | |
| SCHEMBL12898401 | 0.71 | PRKCQ (0.54) | PRKCQMAPK1MAPTKMT2A | |
| SCHEMBL5408522 | 0.69 | LRRK2 (0.65) | PRKCQALKMAPK1INSRCDC7 | |
| SCHEMBL25192890 | 0.69 | CYP1A2 (0.50) | PRKCQMAPK1CLK4MAPTKMT2A | |
| SCHEMBL30443923 | 0.69 | CYP1A2 (0.50) | PRKCQMAPK1CLK4MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |
| EP-2275413-A1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders. | Novartis AG (CH) | 2011-01-19 | — | — | EP | disclosed |