Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.48 |
| ▸ | PLK1 | P53350 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1078874 | 0.83 | PRKCQ (0.49) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL375534 | 0.80 | ZAP70 (0.65) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL6151152 | 0.80 | ZAP70 (0.66) | ALKIGF1RPTK2ZAP70MAPT | |
| SCHEMBL5291264 | 0.75 | ZAP70 (0.47) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL5284498 | 0.73 | MAP4K1 (0.45) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL14735829 | 0.70 | ALK (0.54) | ALKINSRMETAXLAURKB | |
| SCHEMBL28438709 | 0.68 | MAPT (0.52) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL28896784 | 0.68 | PLK1 (0.47) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL5408522 | 0.68 | LRRK2 (0.65) | ALKPLK1MAPK1CDC7PLK4 | |
| SCHEMBL382126 | 0.67 | EGFR (0.70) | ALKINSRIGF1RZAP70EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287156-A1 | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | Novartis AG (CH) | 2011-02-23 | — | — | EP | disclosed |
| EP-2275413-A1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders. | Novartis AG (CH) | 2011-01-19 | — | — | EP | disclosed |