Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 18/20 | 0.53 |
| ▸ | INSR | P06213 | 9/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735829 | 0.85 | ALK (0.54) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL375403 | 0.83 | ALK (0.63) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL382125 | 0.78 | EGFR (0.69) | ALKJAK2SRCTNK2 | |
| SCHEMBL5291249 | 0.74 | ALK (0.48) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL11916628 | 0.72 | ALK (0.77) | ALKINSRAURKAROS1JAK2 | |
| SCHEMBL5284485 | 0.71 | ZAP70 (0.45) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL1078874 | 0.71 | PRKCQ (0.49) | ALKINSRAXLAURKBJAK2 | |
| SCHEMBL24255230 | 0.70 | ALK (0.74) | ALKINSRAXLJAK2SRC | |
| SCHEMBL6151150 | 0.70 | ZAP70 (0.65) | ALK | |
| SCHEMBL20085655 | 0.70 | ALK (0.84) | ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |