Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 16/20 | 0.54 |
| ▸ | INSR | P06213 | 7/20 | 0.53 |
| ▸ | AXL | P30530 | 4/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | ROS1 | P08922 | 3/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14735828 | 0.85 | ALK (0.53) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL375403 | 0.83 | ALK (0.63) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL382126 | 0.77 | EGFR (0.70) | ALKINSR | |
| SCHEMBL5291264 | 0.74 | ZAP70 (0.47) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL11916628 | 0.72 | ALK (0.77) | ALKINSRAURKAROS1MET | |
| SCHEMBL5284498 | 0.71 | MAP4K1 (0.45) | ALKAXLAURKAAURKBMET | |
| SCHEMBL11916467 | 0.70 | ALK (0.70) | ALKINSRAXLAURKAAURKB | |
| SCHEMBL1078876 | 0.70 | ALK (0.48) | ALKINSRAXLAURKBMET | |
| SCHEMBL25566012 | 0.70 | ALK (0.77) | ALKINSRROS1 | |
| SCHEMBL18159081 | 0.70 | ALK (1.00) | ALKINSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2275413-B1 | 2,4-di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders | NOVARTIS AG (CH) | 2013-03-06 | — | — | EP | disclosed |