Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.57 |
| ▸ | ACE | P12821 | 3/20 | 0.53 |
| ▸ | CMA1 | P23946 | 11/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10788783 | 1.00 | KLK5 (0.57) | KLK5ACECMA1ADORA3ADORA2A | |
| SCHEMBL7365238 | 0.88 | ACE (0.54) | ACEACE2 | |
| SCHEMBL7365239 | 0.88 | ACE (0.54) | ACEACE2 | |
| SCHEMBL10785793 | 0.85 | ACE (0.64) | ACECMA1ACE2 | |
| SCHEMBL10785790 | 0.85 | ACE (0.64) | ACECMA1ACE2 | |
| SCHEMBL10657581 | 0.81 | ACE (0.47) | ACECMA1 | |
| SCHEMBL11313573 | 0.79 | KLK5 (0.61) | KLK5ACECMA1ACE2 | |
| SCHEMBL11313575 | 0.79 | KLK5 (0.61) | KLK5ACECMA1ACE2 | |
| SCHEMBL10658161 | 0.77 | ACE (0.52) | ACEACE2 | |
| SCHEMBL10655550 | 0.77 | ACE (0.52) | ACEACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4670541-A | Use of diamino alcohols as analgesic agents | E. R. SQUIBB & SONS, INC. (US) | 1987-06-02 | — | — | US | disclosed |
| US-4552866-A | Use of diamino alcohols as analgesic agents | E. R. SQUIBB & SONS, INC. (US) | 1985-11-12 | — | — | US | disclosed |