Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | RAC1 | P63000 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL149852 | 0.89 | RAC1 (0.56) | KDM4EGAAALDH1A1RAC1MEN1 | |
| SCHEMBL11971636 | 0.74 | ALDH1A1 (0.57) | KDM4EGAAALDH1A1RAC1MEN1 | |
| SCHEMBL11971491 | 0.72 | HMGCR (0.45) | KDM4EGAAALDH1A1RAC1MEN1 | |
| SCHEMBL9830708 | 0.72 | MEN1 (0.44) | KDM4EGAAALDH1A1MEN1KMT2A | |
| SCHEMBL7846522 | 0.71 | KDM4E (0.56) | KDM4EGAAALDH1A1RAC1MEN1 | |
| SCHEMBL11971554 | 0.70 | ALDH1A1 (0.42) | KDM4EGAAALDH1A1RAC1MEN1 | |
| SCHEMBL28662301 | 0.70 | KDM4E (0.57) | KDM4EGAAENPP1MAPTPDE3B | |
| SCHEMBL28311309 | 0.70 | KDM4E (0.57) | KDM4EGAAENPP1MAPTPDE3B | |
| SCHEMBL15586088 | 0.70 | ENPP1 (0.42) | KDM4EGAAALDH1A1MEN1KMT2A | |
| SCHEMBL24393297 | 0.69 | ENPP1 (0.70) | KDM4EALDH1A1ENPP1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4714705-A | 4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction III inhibiting properties and/or renal vasodilating properties | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-12-22 | — | — | US | disclosed |