Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19231462 | 0.80 | CA2 (0.55) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL27947016 | 0.79 | MAPT (0.45) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL9499453 | 0.79 | SMN1; SMN2 (0.45) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL20710538 | 0.76 | MAPT (0.67) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL30405786 | 0.73 | KDM4E (0.57) | SMN1; SMN2CA2CYP1A2KDM4EALDH1A1 | |
| SCHEMBL2799244 | 0.72 | MAPT (0.50) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL10285843 | 0.72 | MAPT (0.50) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL6074279 | 0.71 | BRPF1 (0.59) | MAPTSMN1; SMN2KMT2AGSTP1MEN1 | |
| SCHEMBL3839888 | 0.71 | TNFRSF1A (0.52) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A | |
| SCHEMBL4305274 | 0.71 | MAPT (0.49) | MAPTSMN1; SMN2NPSR1RXFP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268285-A1 | THERAPEUTIC COMPOUNDS | Merck Sharp & Dohme Corp. (US) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009108507-A1 | THERAPEUTIC COMPOUNDS | MERCK & CO., INC. (US) | 2009-09-03 | — | — | WO | disclosed |