Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28587201 | 0.82 | ALDH1A1 (0.56) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL8021776 | 0.79 | TDP1 (0.55) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL8021779 | 0.79 | TDP1 (0.55) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL28552872 | 0.78 | CES1 (0.46) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL28552870 | 0.78 | CES1 (0.46) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL173425 | 0.76 | TSHR (0.62) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL8986220 | 0.76 | CES1 (0.55) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL14710749 | 0.76 | TSHR (0.62) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL173424 | 0.76 | TSHR (0.62) | TSHRCES1CA1CA2TDP1 | |
| SCHEMBL255504 | 0.76 | GSK3B (0.67) | TSHRCES1CA1CA2LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151765-B1 | NOVEL INTERMEDIATES IN A PROCESS FOR MAKING NOVEL 1,2-DIHYDROPYRIDO(3,4-B)-PYRAZINES | Southern Research Institute (US) | 1987-07-08 | — | — | EP | disclosed |
| EP-0061178-B1 | NOVEL 1,2-DIHYDROPYRIDO(3,4-B)-PYRAZINES AND METHOD FOR PREPARING SAME | Southern Research Institute (US) | 1986-02-26 | — | — | EP | disclosed |
| EP-0151765-A2 | Novel intermediates in a process for making novel 1,2-dihydropyrido(3,4-b)-pyrazines | Southern Research Institute (US) | 1985-08-21 | — | — | EP | disclosed |
| US-4511721-A | Intermediate for preparing antifungal 1,2-dihydropyrido[3,4-b]-pyrazines | SOUTHERN RESEARCH INSTITUTE (US) | 1985-04-16 | — | — | US | disclosed |
| US-4450160-A | ANTIDEPRESSANTS | SOUTHERN RESEARCH INSTITUTE (US) | 1984-05-22 | — | — | US | disclosed |
| EP-0061178-A2 | Novel 1,2-dihydropyrido(3,4-b)-pyrazines and method for preparing same | Southern Research Institute (US) | 1982-09-29 | — | — | EP | disclosed |