Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10789833 | 0.93 | CYP11B1 (0.41) | CYP11B1CYP11B2CYP19A1LMNAHTT | |
| SCHEMBL10790079 | 0.83 | HPGDS (0.42) | CYP11B1CYP11B2CYP19A1POLBNPC1 | |
| SCHEMBL10790688 | 0.81 | CYP2C9 (0.38) | LMNA | |
| SCHEMBL10792191 | 0.77 | CYP11B1 (0.39) | CYP11B1CYP11B2CYP19A1LMNAHTT | |
| SCHEMBL10792293 | 0.77 | KDM4C (0.39) | LMNAHTTSMN1; SMN2POLBNPC1 | |
| SCHEMBL10795781 | 0.76 | HPGDS (0.43) | CYP11B1CYP11B2CYP19A1POLBNPC1 | |
| SCHEMBL10792658 | 0.75 | CYP2C9 (0.51) | LMNASMN1; SMN2 | |
| SCHEMBL10792085 | 0.75 | CYP11B1 (0.47) | CYP11B1CYP11B2LMNAHTTSMN1; SMN2 | |
| SCHEMBL2200116 | 0.73 | HPGDS (0.40) | CYP11B1CYP11B2CYP19A1LMNAPOLB | |
| SCHEMBL10795509 | 0.73 | CYP11B1 (0.49) | CYP11B1CYP11B2LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE32400-E | Substituted imidazole derivatives and their use as anti-thrombosis agents | FARMOS YHTYMA OY (FI) | 1987-04-14 | — | — | US | disclosed |
| US-4514412-A | HYPOTENSIVES, BETA BLOCKERS | FARMOS YHTYMA OY (FI) | 1985-04-30 | — | — | US | disclosed |
| EP-0058047-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1984-11-07 | — | — | EP | disclosed |
| EP-0058047-A1 | Substituted imidazole derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1982-08-18 | — | — | EP | disclosed |