Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.37 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10790079 | 0.86 | HPGDS (0.42) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL11049916 | 0.82 | HPGDS (0.43) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL10792191 | 0.80 | CYP11B1 (0.39) | NPC1RAB9AKLKB1CYP11B1CYP11B2 | |
| SCHEMBL10795781 | 0.79 | HPGDS (0.43) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL10793172 | 0.79 | TSHR (0.49) | CYP2C9CYP2C19KDM5AKDM4CKDM5B | |
| SCHEMBL10269258 | 0.78 | CYP19A1 (0.54) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL10792085 | 0.78 | CYP11B1 (0.47) | CYP3A4CYP2C9NPC1RAB9AKDM5A | |
| SCHEMBL10792247 | 0.77 | CYP11B1 (0.39) | KDM5BPHF8P2RX7CYP11B1CYP11B2 | |
| SCHEMBL10789833 | 0.77 | CYP11B1 (0.41) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 | |
| SCHEMBL6896976 | 0.75 | HPGDS (0.50) | HPGDSCYP3A4CYP2D6CYP2E1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079706-B1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS | GRINDEKS JSC (LV) | 2011-07-20 | — | — | EP | disclosed |
| US-7902377-B2 | Method for preparing medetomidine and its salts | JSC GRINDEKS (LV) | 2011-03-08 | — | — | US | disclosed |
| US-20100048915-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. | GRINDEKS A JOINT STOCK COMPANY (LV) | 2010-02-25 | — | — | US | disclosed |
| EP-1918282-A1 | Method for preparing medetomidine and its salts | "Joint Stock Company Grindeks" (LV) | 2008-05-07 | — | — | EP | disclosed |
| US-4684659-A | Antimypertensive substituted imidazoles | FARMOS-YHTYMA OY (FI) | 1987-08-04 | — | — | US | disclosed |
| US-4568686-A | Substituted imidazoles and their use | FARMOS YHTYMA OY (FI) | 1986-02-04 | — | — | US | disclosed |
| EP-0034473-B1 | SUBSTITUTED IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | Farmos-Yhtyma Oy (FI) | 1983-09-21 | — | — | EP | disclosed |
| EP-0034473-A2 | Substituted imidazoles, their preparation and pharmaceutical compositions containing the same | Farmos-Yhtyma Oy (FI) | 1981-08-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048915-A1 | METHOD FOR PREPARING MEDETOMIDINE AND ITS SALTS. | ADRB2, ADRB3, OPRM1 | HPGDS 3213/4885CYP3A4 12/4885CYP2D6 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.