Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 7/20 | 0.51 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.51 |
| ▸ | BRAF | P15056 | 11/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | BTK | Q06187 | 1/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1075954 | 0.94 | BRAF (0.55) | DDR2DDR1BRAF | |
| SCHEMBL1082660 | 0.93 | DDR2 (0.60) | DDR2DDR1BRAFRETABL1 | |
| SCHEMBL1078076 | 0.83 | ALDH1A1 (0.51) | BRAFRAF1LCKKDRJAK3 | |
| SCHEMBL1077356 | 0.83 | DDR2 (0.53) | DDR2DDR1BRAFRETRAF1 | |
| SCHEMBL13219956 | 0.82 | DDR2 (0.61) | DDR2DDR1BRAFRETRAF1 | |
| SCHEMBL1149206 | 0.80 | EGFR (0.63) | BRAFRETABL1SRCKDR | |
| SCHEMBL1078341 | 0.80 | LCK (0.70) | DDR2BRAFRAF1LCKSRC | |
| SCHEMBL1078917 | 0.80 | ABL1 (0.58) | BRAFRAF1ABL1SRCMAPK14 | |
| SCHEMBL1149359 | 0.79 | ABL1 (0.53) | DDR2DDR1BRAFRETRAF1 | |
| SCHEMBL13772007 | 0.78 | DDR2 (0.56) | DDR2DDR1BRAFRETRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2269993-B1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-02-17 | — | — | US | disclosed |
| EP-2269993-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | Kyowa Hakko Kirin Co., Ltd. (JP) | 2011-01-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039845-A1 | 2-AMINOQUINAZOLINE DERIVATIVE | H1-2, H1-3, H1-0 | DDR2 2179/4885DDR1 4042/4885BRAF 2498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.