Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 6/20 | 0.56 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 9/20 | 0.55 |
| ▸ | RAF1 | P04049 | 8/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13219956 | 0.86 | DDR2 (0.61) | DDR2DDR1BRAFRAF1RET | |
| SCHEMBL13765912 | 0.85 | DDR1 (0.66) | DDR2DDR1BRAFRETABL1 | |
| SCHEMBL4467217 | 0.83 | DDR2 (0.60) | DDR2DDR1BRAFRETABL1 | |
| SCHEMBL12871396 | 0.82 | DDR2 (0.63) | DDR2DDR1BRAFRETABL1 | |
| SCHEMBL4467208 | 0.80 | DDR2 (0.59) | DDR2DDR1BRAFRETABL1 | |
| SCHEMBL9611001 | 0.79 | DDR2 (0.65) | DDR2DDR1RETABL1BCR | |
| SCHEMBL13219897 | 0.79 | DDR2 (0.68) | DDR2DDR1RETABL1BCR | |
| SCHEMBL2967106 | 0.79 | DDR1 (0.78) | DDR2DDR1RETABL1BCR | |
| SCHEMBL1079653 | 0.78 | DDR2 (0.51) | DDR2DDR1BRAFRAF1RET | |
| SCHEMBL9611165 | 0.78 | ABL1 (0.64) | DDR2DDR1BRAFRETABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130018046-A1 | Acetylenic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. (US) | 2013-01-17 | — | — | US | disclosed |
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | ARIAD PHARMACEUTICALS, INC. | 2009-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090176781-A1 | Acetylenic Heteroaryl Compounds | NAT1, AADAC, ACACA | DDR2 4117/4885DDR1 4768/4885BRAF 3990/4885 |
| US-20130018046-A1 | Acetylenic Heteroaryl Compounds | NAT1, AADAC, ACACA | DDR2 4117/4885DDR1 4768/4885BRAF 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.