Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.66 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 6/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | EGFR | P00533 | 2/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1630447 | 0.86 | NR4A1 (0.68) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL9787125 | 0.85 | PLA2G4B (0.67) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL6811215 | 0.85 | EGFR (0.68) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL102983 | 0.84 | RAB9A (0.83) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL2503352 | 0.84 | MAOB (0.69) | MAOBNR4A1NR4A2NR4A3SRD5A2 | |
| SCHEMBL433676 | 0.83 | MAOB (0.65) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL6760573 | 0.82 | MAOB (0.60) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL1962776 | 0.82 | MAOB (0.52) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL6533199 | 0.82 | NPC1 (0.69) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 | |
| SCHEMBL1960673 | 0.82 | NR4A1 (0.72) | MAOBNR4A1NR4A2NR4A3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101182289-B | 4'-hydroxy-4,6'-dimethoxy dihydrocharcone and method for synthesizing the same | UNIV SHANGHAI | 2011-03-30 | — | — | CN | claimed |
| CN-101182289-A | 4'-hydroxy-4,6'-dimethoxy dihydrocharcone and method for synthesizing the same | UNIV SHANGHAI (CN) | 2008-05-21 | — | — | CN | claimed |
| CN-111253385-A | Heterocyclic compound, preparation method and application | 遵义医科大学珠海校区 | 2020-06-09 | — | — | CN | disclosed |
| US-20190177327-A1 | SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2019-06-13 | — | — | US | disclosed |
| US-20190177327-A1 | SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS | DART NEUROSCIENCE LLC (US) | 2019-06-13 | — | — | US | disclosed |
| CN-101182289-B | 4'-hydroxy-4,6'-dimethoxy dihydrocharcone and method for synthesizing the same | UNIV SHANGHAI | 2011-03-30 | — | — | CN | disclosed |
| CN-101182289-A | 4'-hydroxy-4,6'-dimethoxy dihydrocharcone and method for synthesizing the same | UNIV SHANGHAI (CN) | 2008-05-21 | — | — | CN | disclosed |
| EP-0113236-B1 | SUBSTITUTED IMIDAZOPYRIMIDINES-PYRAZINES, AND -TRIAZINES | ELI LILLY AND COMPANY (US) | 1987-04-22 | — | — | EP | disclosed |
| US-4636502-A | Methods of producing a positive inotropic effect or vasodilation by administration of 2-phenyl imidazo pyrimidines and pyrazines | ELI LILLY AND COMPANY (US) | 1987-01-13 | — | — | US | disclosed |
| US-4537889-A | PHENYL SUBSTITUTED IMIDAZO COMPOUNDS | ELI LILLY AND COMPANY (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0113236-A1 | Substituted imidazopyrimidines-pyrazines, and -triazines | ELI LILLY AND COMPANY (US) | 1984-07-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177327-A1 | SUBSTITUTED METHYL PYRAZOLOPYRIMIDINONE AND METHYL IMIDAZOPYRAZINONE COMPOUNDS AS PDE1 INHIBITORS | PDE3A, PDE5A, PDE4A | MAOB 1062/4885NR4A1 251/4885NR4A2 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.