Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 10/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 9/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.49 |
| ▸ | EED | O75530 | 2/20 | 0.49 |
| ▸ | SSTR5 | P35346 | 4/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.46 |
| ▸ | TACR1 | P25103 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MLNR | O43193 | 1/20 | 0.46 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HLA-A | P04439 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10549456 | 1.00 | HRH1 (0.49) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL9536666 | 1.00 | HRH1 (0.49) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL9536973 | 0.86 | EED (0.47) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL10549784 | 0.86 | EED (0.47) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL10549770 | 0.86 | EED (0.47) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL10548426 | 0.82 | TP53 (0.49) | HRH1CYP2D6KCNH2CHRM1SSTR5 | |
| SCHEMBL10799113 | 0.80 | LMNA (0.51) | HRH1CYP2D6KCNH2CHRM1EED | |
| SCHEMBL9698401 | 0.80 | SSTR5 (0.60) | HRH1CYP2D6KCNH2CHRM1EED | |
| Hydrochloric Acid SCHEMBL9537106 | 0.77 | HRH1 (0.56) | HRH1CYP2D6KCNH2CHRM1TP53 | |
| Hydrochloric Acid SCHEMBL9537102 | 0.77 | HRH1 (0.56) | HRH1CYP2D6KCNH2CHRM1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4695575-A | ANTIHISTAMINES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-09-22 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |