Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10803043 | 0.84 | TRPA1 (0.38) | TRPA1CYP3A4GPR52SMN1; SMN2PTPN1 | |
| SCHEMBL10738569 | 0.65 | KMT2A (0.51) | SMN1; SMN2POLB | |
| SCHEMBL10733734 | 0.64 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBGRIN2B | |
| SCHEMBL15988633 | 0.64 | TRPA1 (0.69) | TRPA1CYP3A4PTK2GPR52PTPN1 | |
| SCHEMBL11160237 | 0.61 | TSHR (0.41) | CYP3A4POLB | |
| SCHEMBL2379273 | 0.61 | — | — | |
| SCHEMBL6627157 | 0.61 | — | — | |
| SCHEMBL11849341 | 0.61 | — | — | |
| SCHEMBL12430461 | 0.61 | — | — | |
| SCHEMBL7142769 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0044705-B1 | SUBSTITUTED PYRIMIDIN-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A METHOD THEREFOR | GLAXO GROUP LIMITED (GB) | 1984-11-14 | — | — | EP | claimed |
| EP-0044705-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | claimed |
| US-4650800-A | Substituted pyrimidin-2-ones, the salts thereof, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED | 1987-03-17 | — | — | US | disclosed |
| EP-0044705-B1 | SUBSTITUTED PYRIMIDIN-2-ONES, THE SALTS THEREOF, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND A METHOD THEREFOR | GLAXO GROUP LIMITED (GB) | 1984-11-14 | — | — | EP | disclosed |
| EP-0044705-A1 | Substituted pyrimidin-2-ones, the salts thereof, processes for their preparation, pharmaceutical compositions containing them and a method therefor | GLAXO GROUP LIMITED (GB) | 1982-01-27 | — | — | EP | disclosed |