Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 8/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.70 |
| ▸ | AR | P10275 | 3/20 | 0.70 |
| ▸ | F2 | P00734 | 1/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.66 |
| ▸ | NR3C1 | P04150 | 8/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.56 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CNR1 | P21554 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10427903 | 1.00 | PGR (0.70) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL10427859 | 0.94 | PGR (0.66) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL10356203 | 0.94 | PGR (0.66) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL10356202 | 0.94 | PGR (0.66) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL10427789 | 0.92 | PGR (0.64) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL10427790 | 0.92 | PGR (0.64) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL11124571 | 0.92 | ABCB11 (0.79) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL22171557 | 0.92 | ABCB11 (0.79) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL11413999 | 0.92 | ABCB11 (0.79) | PGRCYP3A4ARF2ABCB11 | |
| SCHEMBL11123589 | 0.92 | ABCB11 (0.79) | PGRCYP3A4ARF2ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4701451-A | Novel 6,16-dimethylcorticoids their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1987-10-20 | — | — | US | disclosed |
| US-4555507-A | Novel 6, 16-dimethylcorticoids, their preparation and use | SCHERING AKTIENGESELLSCHAFT (DE) | 1985-11-26 | — | — | US | disclosed |