Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10646470 | 0.96 | HRH3 (0.53) | HRH3SMN1; SMN2GPR119MAOAMAOB | |
| SCHEMBL10650307 | 0.95 | HRH3 (0.52) | HRH3SMN1; SMN2GPR119MAOAMAOB | |
| SCHEMBL10648034 | 0.93 | HRH3 (0.50) | HRH3SMN1; SMN2GPR119PARP1PDE3B | |
| SCHEMBL10650433 | 0.85 | HRH3 (0.46) | HRH3SMN1; SMN2GPR119LMNANPY1R | |
| SCHEMBL10648178 | 0.80 | PDE3B (0.44) | LMNAPDE3BPDE3A | |
| SCHEMBL10806820 | 0.78 | PDE3B (0.46) | HRH3SMN1; SMN2LMNANPY1RNPY2R | |
| SCHEMBL10645518 | 0.77 | PDE3B (0.43) | LMNAPDE3BPDE3A | |
| SCHEMBL10926117 | 0.76 | PDE3B (0.42) | LMNAPDE3BPDE3A | |
| SCHEMBL10977421 | 0.76 | PDE3B (0.42) | LMNAPDE3BPDE3A | |
| SCHEMBL10922175 | 0.76 | PDE3B (0.42) | LMNAPDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0128502-A1 | Substituted 6-(thien-2-yl)-3(2H)-pyridazinones and processes for their preparation | A. Nattermann & Cie. GmbH (DE) | 1984-12-19 | — | — | EP | disclosed |