⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035118 | 0.75 | — | — | |
| Bicarbonate SCHEMBL1080335 | 0.75 | LMNA (0.35) | — | |
| SCHEMBL28141410 | 0.73 | — | — | |
| SCHEMBL11220930 | 0.73 | — | — | |
| Tetrafluoroethylene SCHEMBL28833040 | 0.73 | ALOX15 (0.43) | — | |
| Bicarbonate SCHEMBL28623469 | 0.73 | LMNA (0.33) | — | |
| SCHEMBL28151620 | 0.73 | ALOX15 (0.43) | — | |
| SCHEMBL6215728 | 0.72 | — | — | |
| SCHEMBL2019340 | 0.72 | TSHR (0.38) | — | |
| SCHEMBL28250963 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 85 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605237-A | Preparation method and application of fluoroalkyl ketone compound | 武汉大学 | 2022-06-10 | — | — | CN | claimed |
| CN-1325147-A | Solid or gel electrolyte and cells using same | SONY CORP (JP) | 2001-12-05 | — | — | CN | claimed |
| US-20010020006-A1 | Compounds of unstable DP IV-inhibitors | PROSIDION LIMITED (GB) | 2001-09-06 | — | — | US | claimed |
| JP-57085340-A | — | — | None | — | — | JP | disclosed |
| US-10174077-B2 | Method of inhibiting activity of cell surface fibroblast activation protein alpha | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2019-01-08 | — | — | US | disclosed |
| US-10155789-B2 | Substrates and inhibitors of prolyl oligopeptidase and methods of use thereof | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2018-12-18 | — | — | US | disclosed |
| US-9765033-B2 | Method for the production of 3,5-bis(fluoroalkyl)pyrazole derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2017-09-19 | — | — | US | disclosed |
| US-20170260231-A1 | Substrates and Inhibitors of Prolyl Oligopeptidase and Methods of Use Thereof | UNIV OKLAHOMA (US) | 2017-09-14 | — | — | US | disclosed |
| US-9688722-B2 | Substrates and inhibitors of prolyl oligopeptidase and methods of use | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2017-06-27 | — | — | US | disclosed |
| US-20170066800-A1 | Substrates and Inhibitors of Antiplasmin Cleaving Enzyme and Fibroblast Activation Protein and Methods of Use | UNIV OKLAHOMA (US) | 2017-03-09 | — | — | US | disclosed |
| US-9527884-B2 | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2016-12-27 | — | — | US | disclosed |
| EP-0504064-B1 | Novel thrombin inhibitors | MERRELL PHARMA INC (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1998000439-A2 | MULTIVALENT COMPOUNDS FOR CROSS-LINKING RECEPTORS AND USES THEREOF | TRUSTEES OF TUFTS COLLEGE (US) | 1998-01-08 | — | — | WO | disclosed |
| US-5563156-A | ANTICOAGULANTS, ANTIASTHMA AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1996-10-08 | — | — | US | disclosed |
| US-5498779-A | ANTICOAGULANTS AND TREATMENT OF ASTHMA | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-12 | — | — | US | disclosed |
| US-5391705-A | Anticoagulants, treats thrombophlebitis, coronary thrombosis and asthma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1995-02-21 | — | — | US | disclosed |
| EP-0503203-A1 | Novel thrombin inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0504064-A1 | Novel thrombin inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |
| EP-0254652-A1 | Process for the preparation of perfluoro-alkyl ketones | RHONE-POULENC CHIMIE (FR) | 1988-01-27 | — | — | EP | disclosed |
| JP-S5785340-A | PRODUCTION OF ALPHA-FLUORO-BETA-(ALKYLKETO) ESTER | IHARA CHEM IND CO LTD | 1982-05-28 | — | — | JP | disclosed |