Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.55 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.55 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.55 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.54 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.53 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10803991 | 0.98 | LMNA (0.59) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL9663973 | 0.90 | MEN1 (0.58) | LMNAS1PR1S1PR4S1PR3PLA2G4B | |
| SCHEMBL9662610 | 0.86 | LMNA (0.57) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL4532106 | 0.86 | FFAR1 (0.68) | LMNAL3MBTL1S1PR1S1PR3FFAR1 | |
| SCHEMBL9733807 | 0.86 | LMNA (0.62) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL24723561 | 0.86 | L3MBTL1 (0.82) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL28035324 | 0.86 | PLA2G4B (0.65) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL6497674 | 0.84 | LMNA (0.79) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL2183912 | 0.84 | LMNA (0.79) | LMNAL3MBTL1S1PR1S1PR4S1PR3 | |
| SCHEMBL17345290 | 0.84 | LMNA (0.60) | LMNAL3MBTL1S1PR1S1PR4S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920182-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | Adelaide Research & Innovation Pty Ltd. (AU) | 2015-09-23 | — | — | EP | disclosed |
| WO-2014075146-A1 | MACROCYCLIC COMPOUNDS AND USES THEREOF | ADELAIDE RESEARCH & INNOVATION PTY LTD (AU) | 2014-05-22 | — | — | WO | disclosed |
| US-4686305-A | USED IN LIQUID CRYSTAL DISPLAYS TO LOWER MELTING POINT WITHOUT LOWERING CLEARING POINT | CHISSO CORPORATION (JP) | 1987-08-11 | — | — | US | disclosed |