Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FASN | P49327 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | STS | P08842 | 1/20 | 0.30 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26254861 | 0.60 | HSD17B3 (0.82) | HSD17B3HPGDALDH1A1RECQLTDP1 | |
| SCHEMBL26254903 | 0.60 | HSD17B3 (0.48) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| Propyl 4-Pyridyl Ketone SCHEMBL4952700 | 0.57 | HSD17B3 (0.61) | HSD17B3HPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL3346960 | 0.56 | CTNNB1 (0.58) | HPGDALDH1A1ALOX15TSHRRECQL | |
| SCHEMBL7195006 | 0.56 | HSD17B3 (0.64) | HSD17B3HPGDALDH1A1SMN1; SMN2L3MBTL1 | |
| Butyrophenone SCHEMBL25423577 | 0.56 | L3MBTL1 (0.77) | HSD17B3HPGDALDH1A1ALOX15TDP1 | |
| SCHEMBL19457972 | 0.56 | HSD17B3 (0.48) | HSD17B3HPGDALDH1A1ALOX15TSHR | |
| Butyrophenone SCHEMBL82532 | 0.56 | L3MBTL1 (0.77) | HSD17B3HPGDALDH1A1ALOX15TDP1 | |
| Butyrophenone SCHEMBL9725428 | 0.56 | L3MBTL1 (0.77) | HSD17B3HPGDALDH1A1ALOX15TDP1 | |
| Butyrophenone SCHEMBL11522791 | 0.56 | L3MBTL1 (0.77) | HSD17B3HPGDALDH1A1ALOX15TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0079049-B1 | NOVEL SUBSTITUTED ALKANOYLIMIDAZOL-2-ONE DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4447619-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-05-08 | — | — | US | disclosed |
| EP-0079049-A2 | Novel substituted alkanoylimidazol-2-one derivatives | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-05-18 | — | — | EP | disclosed |
| US-4367236-A | CARDIOTONIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-01-04 | — | — | US | disclosed |