Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 17/20 | 0.73 |
| ▸ | PDE3A | Q14432 | 17/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.57 |
| ▸ | PDE4A | P27815 | 4/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.51 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10993762 | 0.89 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11185074 | 0.89 | PDE3B (0.75) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10814229 | 0.88 | PDE3B (0.70) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11338882 | 0.88 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11196413 | 0.88 | PDE3B (0.73) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11180354 | 0.88 | PDE3B (0.77) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL7312486 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10474968 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL10474439 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 | |
| SCHEMBL11189228 | 0.87 | PDE3B (0.72) | PDE3BPDE3AKDM4EALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089528-B1 | 6-ARYL-4,5-DIHYDRO-3(2H)-PYRIDAZINONES, THEIR PREPARATION AND USE | BASF Aktiengesellschaft (DE) | 1987-05-27 | — | — | EP | disclosed |
| US-4544562-A | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, and their use as anti-hypertensive and anti-thrombocyte agents | BASF AKTIENGESELLSCHAFT (DE) | 1985-10-01 | — | — | US | disclosed |
| EP-0089528-A1 | 6-Aryl-4,5-dihydro-3(2H)-pyridazinones, their preparation and use | BASF Aktiengesellschaft (DE) | 1983-09-28 | — | — | EP | disclosed |