Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10808988 | 0.81 | GAA (0.43) | GAABLMNPSR1ALDH1A1ERN1 | |
| SCHEMBL16865527 | 0.81 | ACHE (0.38) | GAATSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL16865535 | 0.81 | ACHE (0.38) | GAATSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL16865534 | 0.81 | ACHE (0.38) | GAATSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL16212392 | 0.79 | GAA (0.38) | GAATSHRBLMNPSR1ALDH1A1 | |
| SCHEMBL26090280 | 0.78 | BCHE (0.38) | GAATSHRBLMNPSR1ACHE | |
| SCHEMBL16865515 | 0.78 | BCHE (0.38) | GAATSHRBLMNPSR1ACHE | |
| SCHEMBL6129098 | 0.77 | ACHE (0.43) | GAAALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL31465578 | 0.74 | LMNA (0.54) | ALDH1A1HDAC4HDAC8ACHEBCHE | |
| SCHEMBL358026 | 0.74 | LMNA (0.54) | ALDH1A1HDAC4HDAC8ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210828-A2 | Tetrahydroisoquinoline derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITHKLINE BEECHAM CORPORATION (US) | 1987-02-04 | — | — | EP | disclosed |