Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.72 |
| ▸ | RAB9A | P51151 | 12/20 | 0.72 |
| ▸ | MEN1 | O00255 | 7/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.72 |
| ▸ | MAPT | P10636 | 7/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.72 |
| ▸ | RELA | Q04206 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HPGD | P15428 | 1/20 | 0.72 |
| ▸ | MPI | P34949 | 1/20 | 0.72 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.72 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.72 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10804473 | 0.86 | NPC1 (0.69) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL23715 | 0.82 | NPC1 (0.70) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL4918595 | 0.82 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL15993384 | 0.81 | DYRK1A (0.67) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2114859 | 0.81 | NPC1 (0.68) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL10807219 | 0.81 | NPC1 (0.74) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL1307056 | 0.81 | MAPT (0.82) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL5653636 | 0.80 | CASP2 (0.77) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL16681363 | 0.80 | SCD (0.88) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL11549742 | 0.80 | NPC1 (0.76) | NPC1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0093515-B1 | TRICYCLIC TRIAZINO COMPOUNDS, THEIR USE AND FORMULATION AS PHARMACEUTICALS AND PROCESSES FOR THEIR PRODUCTION | FISONS plc (GB) | 1987-01-21 | — | — | EP | disclosed |
| US-4499269-A | IMMUNO-REGULANT, SKIN DISORDERS, ANTITUMOR AGENTS | FISONS PLC (GB) | 1985-02-12 | — | — | US | disclosed |
| EP-0093515-A1 | Tricyclic triazino compounds, their use and formulation as pharmaceuticals and processes for their production | FISONS plc (GB) | 1983-11-09 | — | — | EP | disclosed |