Sugi Predict

Sugi Predict / Compounds / SCHEMBL2114859

SCHEMBL2114859

SCHEMBL2114859

COc1ccc2nc(NN)sc2c1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NPC1 O15118 10/20 0.68
▸ RAB9A P51151 10/20 0.68
▸ SMN1; SMN2 Q16637 10/20 0.68
▸ MEN1 O00255 10/20 0.68
▸ KMT2A Q03164 10/20 0.68
▸ MAPT P10636 10/20 0.68
▸ HTT P42858 5/20 0.65
▸ NFKB1 P19838 3/20 0.65
▸ NFKB2 Q00653 3/20 0.65
▸ RELA Q04206 3/20 0.65
▸ CYP1A2 P05177 2/20 0.65
▸ CYP3A4 P08684 2/20 0.65
▸ CYP2C19 P33261 2/20 0.65
▸ DYRK1A Q13627 1/20 0.65
▸ ALDH1A1 P00352 6/20 0.63
▸ GAA P10253 2/20 0.63
▸ LMNA P02545 5/20 0.60
▸ TDP1 Q9NUW8 3/20 0.60
▸ SCD O00767 3/20 0.60
▸ HPGD P15428 3/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1307056 0.87 MAPT (0.82) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL8280120 0.85 NPC1 (0.70) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2076821 0.83 SMN1; SMN2 (0.67) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL17987870 0.83 LMNA (0.56) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2759560 0.81 RAB9A (0.65) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2733120 0.81 NPC1 (0.65) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL22600051 0.81 ATAD2 (0.65) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL2116986 0.81 NPC1 (0.68) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL10804473 0.81 NPC1 (0.69) NPC1RAB9ASMN1; SMN2MEN1KMT2A
SCHEMBL10810325 0.81 NPC1 (0.72) NPC1RAB9ASMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112341471-A Rhodamine-benzothiazole functionalized photosensitive probe, and synthetic method and application thereof 西安科技大学 2021-02-09 — — CN claimed
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2016-06-23 — — US claimed
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH 2012-04-19 — — US claimed
US-20030072725-A1 Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles HAARMANN & REIMER GMBH (DE) 2003-04-17 — — US claimed
EP-1259219-A2 TOPICAL COSMETIC AGENTS CONTAINING 2-HYDRAZINO-1,3-HETEROAZOLES HAARMANN & REIMER GMBH (DE) 2002-11-27 — — EP claimed
US-20020128268-A1 Use of 2-hydrazino-1,3-thiazoles as antioxidants HAARMANN & REIMER GMBH (DE) 2002-09-12 — — US claimed
WO-2002034265-A1 USE OF 2-HYDRAZINO-1,3-THIAZOLES AS ANTIOXIDANTS HAARMANN & REIMER GMBH (DE) 2002-05-02 — — WO claimed
WO-2001062208-A2 TOPICAL COSMETIC AGENTS CONTAINING 2-HYDRAZINO-1,3-HETEROAZOLES HAARMANN & REIMER GMBH (DE) 2001-08-30 — — WO claimed
EP-3990569-B1 NEW POLYMERIZABLE LIQUID CRYSTAL ROLIC TECH AG (CH) 2024-12-04 — — EP disclosed
WO-2024202448-A1 BIOLOGICAL COMPONENT CONCENTRATION MEASUREMENT REAGENT, MEASUREMENT METHOD, AND SENSOR テルモ株式会社 2024-10-03 — — WO disclosed
CN-118702646-A Novel polymerizable liquid crystal 罗利克技术有限公司 2024-09-27 — — CN disclosed
EP-4428532-A1 BIOLOGICAL COMPONENT CONCENTRATION MEASUREMENT REAGENT, MEASUREMENT METHOD, AND SENSOR Terumo Kabushiki Kaisha (JP) 2024-09-11 — — EP disclosed
CN-118176419-A Reagent for measuring concentration of biological component, measuring method, and sensor 泰尔茂株式会社 2024-06-11 — — CN disclosed
CN-114026078-B Novel polymerizable liquid crystal 罗利克技术有限公司 2024-06-07 — — CN disclosed
US-20050096471-A1 Process for producing biaryl compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-05-05 — — US disclosed
EP-1473286-A1 PROCESS FOR PRODUCING BIARYL COMPOUND Sumitomo Chemical Company, Limited (JP) 2004-11-03 — — EP disclosed
US-20030072725-A1 Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles HAARMANN & REIMER GMBH (DE) 2003-04-17 — — US disclosed
WO-2001049686-A1 S-TRIAZINE DERIVATIVES AND THEIR USE AS UV FILTERS L'OREAL (FR) 2001-07-12 — — WO disclosed
US-5242940-A Antiinflammatory agents ORTHO PHARMACEUTICAL CORPORATION (US) 1993-09-07 — — US disclosed
US-3937714-A 2-AMINOBENZOTHIAZOLES, HYDRAZINE, ACID CATALYSTS ELI LILLY AND COMPANY (US) 1976-02-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020128268-A1 Use of 2-hydrazino-1,3-thiazoles as antioxidants GPX1, LPO, GPX4 NPC1 1079/4885RAB9A 3084/4885SMN1; SMN2 3373/4885
US-20160175303-A1 SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, TBCA, SDHA NPC1 1681/4885RAB9A 2476/4885SMN1; SMN2 4865/4885
US-20120095021-A1 SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS TST, SDHB, SDHA NPC1 2311/4885RAB9A 4194/4885SMN1; SMN2 3952/4885
US-20050096471-A1 Process for producing biaryl compound PPOX, CAT, TYR NPC1 4102/4885RAB9A 2254/4885SMN1; SMN2 4152/4885
US-20030072725-A1 Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles TYR, MITF, HDAC1 NPC1 2397/4885RAB9A 2330/4885SMN1; SMN2 4816/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.