Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | AHR | P35869 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13175943 | 0.83 | DYRK1A (0.51) | PDE3BPDE3ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL30189256 | 0.80 | GRIN1 (0.50) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL24113095 | 0.80 | GRIN1 (0.50) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL10810922 | 0.80 | KDM4E (0.57) | PDE3BPDE3ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL27626392 | 0.80 | KDM4E (0.44) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL24020812 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL30310570 | 0.80 | KDM4E (0.48) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| Hydrochloric Acid SCHEMBL29761726 | 0.78 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL17531158 | 0.74 | PDE3B (0.56) | PDE3BPDE3ADYRK1AKDM4EALDH1A1 | |
| SCHEMBL23147745 | 0.73 | NUDT1 (0.44) | KDM4EHPGDPIN1GPR35DAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268854-B2 | Aza-beta-carbolines and methods of using same | THE UWM RESEARCH FOUNDATION, INC. (US) | 2012-09-18 | — | — | US | disclosed |
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-12-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306121-A1 | AZA-BETA-CARBOLINES AND METHODS OF USING SAME | CHRNA7, CHRNA2, CHRNA5 | PDE3B 101/4885PDE3A 176/4885DYRK1A 3654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.