Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methacrylic Acid SCHEMBL238111 | 0.97 | — | — | |
| Methacrylic Acid SCHEMBL10804851 | 0.97 | ALDH1A1 (0.42) | FFAR3LCKFYNALDH1A1TDP1 | |
| Methacrylic Acid SCHEMBL4727069 | 0.94 | ALDH1A1 (0.40) | FFAR3LCKFYNALDH1A1TDP1 | |
| Methacrylic Acid SCHEMBL27577962 | 0.92 | ALDH1A1 (0.38) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL27698447 | 0.87 | FFAR3 (0.54) | FFAR3LCKFYNALDH1A1TDP1 | |
| Acetic Acid SCHEMBL440991 | 0.87 | — | — | |
| Acetic Acid SCHEMBL11324300 | 0.84 | — | — | |
| Methacrylic Acid SCHEMBL8426536 | 0.84 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1TDP1 | |
| Methacrylic Acid SCHEMBL10339749 | 0.84 | — | — | |
| Methacrylic Acid SCHEMBL28106790 | 0.84 | FFAR3 (0.58) | FFAR3LCKFYNALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4692491-A | ADDITION POLYMER CONTAINING EPOXY MONOMER, ACRYLIC POLYMER SURFACTANT | PPG INDUSTRIES, INC. (US) | 1987-09-08 | — | — | US | disclosed |
| US-4647612-A | GLYCIDYL (METH)ACRYLATE, POLYMERIC CARBOXYLIC ACID SALT SURFACTANT | PPG INDUSTRIES, INC. (US) | 1987-03-03 | — | — | US | disclosed |