Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10664070 | 0.72 | MAPT (0.60) | MPLPARP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL3212830 | 0.68 | NPC1 (0.50) | PARP1MAPTHTR1AADRB2ADRB1 | |
| SCHEMBL29754448 | 0.68 | NPC1 (0.50) | PARP1MAPTHTR1AADRB2ADRB1 | |
| SCHEMBL1764170 | 0.68 | NPC1 (0.50) | PARP1MAPTHTR1AADRB2ADRB1 | |
| SCHEMBL28902429 | 0.67 | MPL (0.55) | MPLHTR6DRD2SMN1; SMN2MAPT | |
| SCHEMBL6385170 | 0.66 | HTR6 (0.55) | MPLHTR6DRD2SMN1; SMN2MAPT | |
| SCHEMBL10661877 | 0.66 | GRIA1 (0.54) | MPLPARP1SMN1; SMN2MAPTALDH1A1 | |
| Bromide SCHEMBL7314028 | 0.65 | GRIA1 (0.53) | MPLPARP1SMN1; SMN2MAPTALDH1A1 | |
| Hydrochloric Acid SCHEMBL10662967 | 0.65 | GRIA1 (0.53) | MPLPARP1SMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL10659206 | 0.65 | BACE1 (0.36) | HTR1AADRB2ADRB1OPRK1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0207140-A4 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES. | RORER INTERNAT OVERSEAS INC (US) | 1987-06-15 | — | — | EP | claimed |
| EP-0207140-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (a Delaware corporation) (US) | 1987-01-07 | — | — | EP | claimed |
| WO-1986003749-A1 | BICYCLIC HETEROARYL THIAZOLE COMPOUNDS, CARDIOTONIC COMPOSITIONS INCLUDING THE SAME, AND THEIR USES | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1986-07-03 | — | — | WO | claimed |