Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10815783 | 0.82 | MEN1 (0.50) | ADORA2AADORA1ADORA2BKMT2AMEN1 | |
| SCHEMBL10810284 | 0.75 | ADORA1 (0.48) | ADORA2AADORA1ADORA2BPTGS1PTGS2 | |
| SCHEMBL10812248 | 0.74 | KMT2A (0.39) | ADORA2AADORA1PTGS2KMT2AMEN1 | |
| SCHEMBL10810550 | 0.74 | NPSR1 (0.53) | ADORA2AADORA1ADORA2BPTGS1PTGS2 | |
| SCHEMBL11193275 | 0.69 | MEN1 (0.43) | ADORA2AADORA1ADORA2BKMT2AMEN1 | |
| SCHEMBL11191145 | 0.69 | MAOB (0.50) | PTGS1PTGS2KMT2AMEN1 | |
| SCHEMBL15038415 | 0.68 | ADORA2A (0.53) | ADORA2AADORA1ADORA2BPTGS1PTGS2 | |
| SCHEMBL10814458 | 0.68 | KDM4E (0.46) | ADORA2AADORA1KMT2AMEN1TP53 | |
| SCHEMBL11187012 | 0.66 | KDM4E (0.47) | KMT2AMEN1TP53 | |
| SCHEMBL10843457 | 0.66 | ADORA2A (0.71) | ADORA2AADORA1ADORA2BDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0077983-B1 | TRIAZINE DERIVATIVES, PROCESSES FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1987-04-29 | — | — | EP | disclosed |
| US-4616014-A | HYPOTENSIVE AGENTS, ANTICOAGULANTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-10-07 | — | — | US | disclosed |
| EP-0077983-A1 | Triazine derivatives, processes for preparation thereof and pharmaceutical compositions comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-05-04 | — | — | EP | disclosed |