Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | CTH | P32929 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8486373 | 0.87 | KMT2A (0.33) | MAPTLMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL10815656 | 0.87 | TOP2A (0.47) | TOP2AMAPTLMNAALDH1A1POLB | |
| SCHEMBL8487270 | 0.84 | TOP2A (0.41) | TOP2A | |
| SCHEMBL8487902 | 0.84 | MAPT (0.35) | MAPTLMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL8483564 | 0.82 | TOP2A (0.41) | TOP2A | |
| SCHEMBL8485627 | 0.82 | TOP2A (0.41) | TOP2AMAPTKDM4EHTTRAB9A | |
| SCHEMBL8485482 | 0.82 | NQO1 (0.41) | TOP2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL8487670 | 0.80 | TOP2A (0.41) | TOP2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL8483473 | 0.79 | TOP2A (0.42) | TOP2A | |
| SCHEMBL8485535 | 0.74 | NQO1 (0.36) | TOP2AMAPTLMNAALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935969-A | Pyrido-thiopyrandoinazoles with antitumor activity | UNIVERSITY OF VERMONT (US) | 1999-08-10 | — | — | US | disclosed |