Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.65 |
| ▸ | RAB9A | P51151 | 4/20 | 0.65 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 3/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10817027 | 1.00 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL8085252 | 0.88 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL15571574 | 0.88 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL8085249 | 0.88 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL10805356 | 0.85 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL10805360 | 0.85 | PIM1 (0.67) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL5746497 | 0.85 | NPC1 (0.69) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL5746504 | 0.85 | NPC1 (0.69) | PIM1PIM2HPGDKMT2AMEN1 | |
| SCHEMBL2545596 | 0.81 | PIM1 (1.00) | PIM1PIM2HPGDRAB9ANPC1 | |
| SCHEMBL2545594 | 0.81 | PIM1 (1.00) | PIM1PIM2HPGDRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137083-B1 | 1,5-BENZOTHIAZEPINE DERIVATIVES AND PRODUCTION THEREOF | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. (JP) | 1987-06-24 | — | — | EP | disclosed |
| EP-0137083-A1 | 1,5-Benzothiazepine derivatives and production thereof | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. (JP) | 1985-04-17 | — | — | EP | disclosed |
| US-4490292-A | 1,5-Benzothiazepine derivatives and production thereof | HAMARI CHEMICALS, LTD. (JP) | 1984-12-25 | — | — | US | disclosed |