Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.69 |
| ▸ | RAB9A | P51151 | 3/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.69 |
| ▸ | PIM1 | P11309 | 3/20 | 0.69 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.63 |
| ▸ | CLK1 | P49759 | 1/20 | 0.63 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.63 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.63 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 4/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5746504 | 1.00 | NPC1 (0.69) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL10817032 | 0.85 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL10817027 | 0.85 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL8085252 | 0.84 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL8085249 | 0.84 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL15571574 | 0.84 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL1247708 | 0.82 | PIM1 (1.00) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL2546911 | 0.82 | PIM1 (1.00) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL1247705 | 0.82 | PIM1 (1.00) | NPC1RAB9AAKR1B1PIM1PIM2 | |
| SCHEMBL10805356 | 0.82 | PIM1 (0.67) | NPC1RAB9AAKR1B1PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1173427-B1 | HYDROXAMIC ACID DERIVATIVE | DAINIPPON SUMITOMO PHARMA CO (JP) | 2006-04-05 | — | — | EP | disclosed |
| US-6713477-B1 | 1,4-BENZTHIAZINES OR BENZOXAZINES; MATRIX METALLOPROTEINASE INHIBITORS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2004-03-30 | — | — | US | disclosed |