Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.67 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.67 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.67 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NAT1 | P18440 | 2/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8085252 | 1.00 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL15571574 | 1.00 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL10805356 | 0.88 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL10817027 | 0.88 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL10805360 | 0.88 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL10817032 | 0.88 | PIM1 (0.67) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL5746497 | 0.84 | NPC1 (0.69) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL5746504 | 0.84 | NPC1 (0.69) | PIM1PIM3PIM2NPC1RAB9A | |
| SCHEMBL1250387 | 0.80 | PIM1 (1.00) | PIM1PIM3PIM2RAB9ANAT1 | |
| SCHEMBL211085 | 0.80 | PIM1 (1.00) | PIM1PIM3PIM2RAB9ANAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0137083-A1 | 1,5-Benzothiazepine derivatives and production thereof | HAMARI YAKUHIN KOGYO KABUSHIKI KAISHA also known as HAMARI CHEMICALS, LTD. (JP) | 1985-04-17 | — | — | EP | claimed |
| EP-0627425-B1 | 3-OXO-1,4-BENZOTHIAZINE DERIVATIVE | SANTEN PHARMACEUTICAL CO LTD (JP) | 2000-11-02 | — | — | EP | disclosed |
| EP-0657444-B1 | 3-Oxo-1,4-benzothiazine derivates | SANTEN PHARMACEUTICAL CO LTD (JP) | 1999-03-31 | — | — | EP | disclosed |
| EP-0666261-B1 | Thiazine or thiomorpholine derivatives | SANTEN PHARMACEUTICAL CO LTD (JP) | 1997-05-07 | — | — | EP | disclosed |
| US-5556841-A | TREATMENT OF CATARACTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5547952-A | TREATMENT OF CATARACTS | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-08-20 | — | — | US | disclosed |
| US-5496817-A | TREATMENT OF CATARACTS; SUPPRESSION OF LIPID PEROXIDE FORMATION | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| EP-0666261-A1 | Novel thiazine or thiomorpholine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0657444-A1 | Novel 3-oxo-1, 4-benzothiazine derivatives | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1995-06-14 | — | — | EP | disclosed |
| EP-0627425-A1 | 3-OXO-1,4-BENZOTHIAZINE DERIVATIVE | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 1994-12-07 | — | — | EP | disclosed |
| US-3923709-A | 3,4-Dihydro-3-oxo-2H-1,4-benzothiazines and benzoxazines | MONSANTO CO | 1975-12-02 | — | — | US | disclosed |