Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HBB | P68871 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 4/20 | 0.44 |
| ▸ | RECQL | P46063 | 4/20 | 0.44 |
| ▸ | BLM | P54132 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10839199 | 0.92 | MAPT (0.55) | MAPTTP53ALDH1A1LMNACYP1A2 | |
| SCHEMBL10839592 | 0.90 | MAPT (0.53) | MAPTTP53HSD17B10USP2ALOX15 | |
| SCHEMBL10818213 | 0.90 | MEN1 (0.53) | MAPTTP53ALOX15TSHRPOLB | |
| SCHEMBL10818216 | 0.88 | MAPT (0.50) | MAPTTP53TSHRPOLBRECQL | |
| SCHEMBL10818115 | 0.85 | MAPT (0.51) | MAPTTP53HSD17B10USP2ALOX15 | |
| SCHEMBL10815354 | 0.83 | L3MBTL1 (0.49) | MAPTTP53POLBRECQLBLM | |
| SCHEMBL10812773 | 0.80 | MAPT (0.55) | MAPTTP53CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10816008 | 0.80 | MEN1 (0.45) | MAPTTP53ALDH1A1TSHRPOLB | |
| SCHEMBL10812478 | 0.75 | L3MBTL1 (0.58) | MAPTTP53POLBRECQLBLM | |
| SCHEMBL10817930 | 0.74 | TP53 (0.55) | MAPTTP53POLBRECQLBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144594-B1 | Derivatives of 5H-[1]benzopyrano-[2,3-d]-pyrimidines, process for their preparation and medicines containing them, useful against gastral and duodenal lesions of the mucosa | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1987-10-07 | — | — | EP | disclosed |
| US-4578380-A | 5H-[1]benzopyrano[2,3-d]pyrimidine derivatives useful for controlling lesions of the gastric and duodenal mucous membranes | WARNER-LAMBERT COMPANY (US) | 1986-03-25 | — | — | US | disclosed |
| EP-0144594-A1 | Derivatives of 5H-[1]benzopyrano-[2,3-d]-pyrimidines, process for their preparation and medicines containing them, useful against gastral and duodenal lesions of the mucosa | GÖDECKE AKTIENGESELLSCHAFT (DE) | 1985-06-19 | — | — | EP | disclosed |