Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17455071 | 0.92 | ALDH1A1 (0.64) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL10666473 | 0.89 | ALDH1A1 (0.63) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL10494904 | 0.88 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL11167696 | 0.88 | ALDH1A1 (0.61) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL10828250 | 0.85 | FAAH (0.64) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL2091191 | 0.84 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL15682719 | 0.84 | MAPT (0.63) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL10828257 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MAPTTSHRKDM4E | |
| SCHEMBL9472298 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1MEN1GAAMAPT | |
| SCHEMBL28912292 | 0.83 | KDM4E (0.61) | SMN1; SMN2ALDH1A1MEN1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008152142-A1 | 2 -AMINOQUINAZOLINE DERIVATIVES AND THEIR THERAPEUTIC USES | SOFTCURE PHARMACEUTICALS AB (SE) | 2008-12-18 | — | — | WO | disclosed |
| EP-0210857-A1 | Process for the preparation of alkyl 2-carboalkoxy-3,4-dialkoxybenzenecarbamates | ORTHO PHARMACEUTICAL CORPORATION (US) | 1987-02-04 | — | — | EP | disclosed |
| US-4617417-A | Alkyl 2-carboalkoxy-3,4-dialkoxybenzenecarbamates and process for their preparation | ORTHO PHARMACEUTICAL CORPORATION (US) | 1986-10-14 | — | — | US | disclosed |