SCHEMBL10817899

SCHEMBL10817899

C[P+](c1ccccc1)(c1ccccc1)c1ccccc1.O=[Mn](=O)(=O)[O-]

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 1/20 0.35
GAA P10253 1/20 0.33
CES2 O00748 1/20 0.32
CES1 P23141 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
ALDH1A1 P00352 3/20 0.31
MAPT P10636 2/20 0.31
MEN1 O00255 1/20 0.31
KMT2A Q03164 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
CYP1A2 P05177 1/20 0.31
CYP2D6 P10635 1/20 0.31
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.31
PTGS2 P35354 1/20 0.30
LMNA P02545 1/20 0.30
XBP1 P17861 1/20 0.30
ATM Q13315 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8374779 0.85 CES2 (0.31) CES2CES1ALDH1A1CYP1A2CYP2D6
SCHEMBL8375250 0.85 CES2 (0.31) CES2CES1ALDH1A1CYP1A2CYP2D6
SCHEMBL8376089 0.85 CES2 (0.31) CES2CES1ALDH1A1CYP1A2CYP2D6
SCHEMBL7237367 0.84 HIF1A (0.41) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
SCHEMBL29371667 0.84 HIF1A (0.45) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
Bromide SCHEMBL3076 0.81 HIF1A (0.43) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
Iodide SCHEMBL42631 0.81 HIF1A (0.43) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
Water SCHEMBL2821350 0.81 HIF1A (0.43) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
Fluoride Ion SCHEMBL4615710 0.81 HIF1A (0.43) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6
Bromide SCHEMBL29712281 0.81 HIF1A (0.43) HIF1ATDP1ALDH1A1L3MBTL1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4713455-A FOR OBSTRUCTIVE DISORDERS OF THE RESPIRATORY TRACT HOECHST AKTIENGESELLSCHAFT (DE) 1987-12-15 US disclosed
US-4616020-A TREATING OBSTRUCTIVE RESPIRATORY DISEASES HOECHST AKTIENGESELLSCHAFT (DE) 1986-10-07 US disclosed
EP-0075850-B1 PHARMACEUTICAL PREPARATIONS CONTAINING VICINAL DIHYDROXYALKYL XANTHINES, PROCESS FOR THE PREPARATION OF THE XANTHINES AND THE APPROPRIATE INTERMEDIATES THEREFOR HOECHST AKTIENGESELLSCHAFT (DE) 1985-12-18 EP disclosed