Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.33 |
| ▸ | CDK1 | P06493 | 5/20 | 0.33 |
| ▸ | CDK9 | P50750 | 2/20 | 0.33 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.31 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10818085 | 0.86 | CDK1 (0.40) | CDK5CDK5R1CDK2CDK1CCNB1 | |
| SCHEMBL10817682 | 0.86 | HDAC1 (0.38) | CDK5CDK5R1CDK2CDK1CCNB1 | |
| SCHEMBL11096314 | 0.84 | CDK5 (0.38) | CDK5CDK5R1CDK2CDK1CDK9 | |
| SCHEMBL9583290 | 0.79 | CDK5 (0.42) | CDK5CDK5R1CDK2CDK1CDK9 | |
| SCHEMBL10812769 | 0.79 | MAPT (0.35) | CDK2CDK1CCNB1MAPT | |
| SCHEMBL10818024 | 0.79 | PDE3A (0.35) | CDK2P2RY1 | |
| SCHEMBL10814186 | 0.77 | YTHDC1 (0.39) | P2RY1 | |
| SCHEMBL10816708 | 0.74 | CDK2 (0.37) | CDK5CDK5R1CDK2CDK1CDK9 | |
| SCHEMBL10814378 | 0.73 | CCNB2 (0.43) | CDK1CCNB2CCNB1CCNB3P2RY1 | |
| SCHEMBL10815977 | 0.73 | CDK5 (0.35) | CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0105135-B1 | SUBSTITUTED 9-(1-0- OR 3-0-MONOSUBSTITUTED OR 1,3-DI-0-SUBSTITUTED 1,3 DIHYDROXY-2-PROPOXYMETHYL) PURINES AS ANTIVIRAL AGENTS | SYNTEX (U.S.A.) INC. (US) | 1987-03-18 | — | — | EP | disclosed |
| US-4609661-A | HERPES VIRUS | SYNTEX (U.S.A.) INC. (US) | 1986-09-02 | — | — | US | disclosed |
| US-4556659-A | Substituted 9-(1-0- or 3-0-monosubstituted or 1,3-Di-0-substituted propoxymethyl)-purines as antiviral agents | SYNTEX (U.S.A.) INC. (US) | 1985-12-03 | — | — | US | disclosed |