Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662439 | 0.89 | KDM4E (0.46) | L3MBTL1KDM4ETDP1ALDH1A1FFAR4 | |
| SCHEMBL661988 | 0.88 | L3MBTL1 (0.47) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL8262745 | 0.81 | L3MBTL1 (0.49) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL13490743 | 0.77 | L3MBTL1 (0.63) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL27854474 | 0.76 | L3MBTL1 (0.44) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL13490831 | 0.73 | KDM4E (0.47) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL8264213 | 0.73 | KDM4E (0.47) | L3MBTL1KDM4ETDP1ALDH1A1SLC5A2 | |
| SCHEMBL3209341 | 0.72 | ALDH1A1 (0.41) | ALDH1A1TUBB1ERN1 | |
| SCHEMBL8421788 | 0.72 | ERN1 (0.65) | TUBB1ERN1 | |
| SCHEMBL533873 | 0.71 | SLC6A4 (0.41) | KDM4ETDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2274295-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009135299-A1 | 3, 4 - SUBSTITUTED PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-11-12 | — | — | WO | disclosed |