Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 17/20 | 0.67 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1297983 | 0.85 | KDM4E (0.54) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL5619518 | 0.80 | DHODH (0.79) | DHODHPARP1 | |
| SCHEMBL505556 | 0.80 | DHODH (1.00) | DHODHPARP1 | |
| SCHEMBL10212043 | 0.79 | DHODH (0.98) | DHODHPARP1 | |
| SCHEMBL6950091 | 0.78 | DHODH (0.69) | DHODHPARP1KDM4EHPGDSRD5A2 | |
| SCHEMBL10688649 | 0.77 | DHODH (0.67) | DHODHPARP1KDM4EHPGDSRD5A2 | |
| SCHEMBL10212006 | 0.77 | DHODH (0.77) | DHODHPARP1 | |
| SCHEMBL10211938 | 0.76 | DHODH (1.00) | DHODHPARP1 | |
| SCHEMBL4243578 | 0.75 | DHODH (0.53) | DHODHPARP1KDM4EHPGD | |
| SCHEMBL6948954 | 0.75 | NPC1 (0.55) | DHODHPARP1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2273879-A1 | PROLYL HYDROXYLASE INHIBITORS | GlaxoSmithKline LLC (US) | 2011-01-19 | — | — | EP | disclosed |
| WO-2009134850-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-05 | — | — | WO | disclosed |