Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | DHODH | Q02127 | 11/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 3/20 | 0.50 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | BRS3 | P32247 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412049 | 0.89 | PARP1 (0.60) | NPC1RAB9ADHODHPARP1 | |
| SCHEMBL6945364 | 0.89 | RAB9A (0.52) | NPC1RAB9ADHODHPARP1RNASEH1 | |
| SCHEMBL6950091 | 0.88 | DHODH (0.69) | DHODHKDM4EHPGDPARP1HDAC6 | |
| SCHEMBL6946473 | 0.87 | NPC1 (0.50) | NPC1RAB9ADHODHPARP1RNASEH1 | |
| SCHEMBL6949168 | 0.84 | DHODH (0.45) | NPC1RAB9ADHODHPARP1RNASEH1 | |
| SCHEMBL9224298 | 0.84 | KDM4E (0.54) | DHODHKDM4EHPGDPARP1 | |
| SCHEMBL6943109 | 0.83 | RAB9A (0.47) | NPC1RAB9ADHODHPARP1RNASEH1 | |
| SCHEMBL6942886 | 0.83 | PARP1 (0.48) | NPC1RAB9AKDM4EPARP1 | |
| SCHEMBL6948942 | 0.82 | BRD4 (0.50) | NPC1RAB9ADHODHKDM4EPARP1 | |
| SCHEMBL6950048 | 0.82 | RNASEH1 (0.50) | NPC1RAB9ADHODHRNASEH1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |