Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 13/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.48 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.48 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.45 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6948954 | 0.88 | NPC1 (0.55) | DHODHPARP1HDAC6KDM4EHPGD | |
| SCHEMBL6948956 | 0.88 | DHODH (0.54) | DHODHHDAC3PARP1HDAC4HDAC1 | |
| SCHEMBL6948273 | 0.84 | DHODH (0.51) | DHODHHDAC3PARP1HDAC4HDAC1 | |
| SCHEMBL6952578 | 0.82 | DHODH (0.52) | DHODHFFAR1FFAR4NR4A1NR4A2 | |
| SCHEMBL505556 | 0.82 | DHODH (1.00) | DHODHHDAC3PARP1HDAC4HDAC1 | |
| SCHEMBL10212043 | 0.81 | DHODH (0.98) | DHODHHDAC3PARP1HDAC4HDAC1 | |
| SCHEMBL6949168 | 0.79 | DHODH (0.45) | DHODHPARP1HDAC1HDAC6BRS3 | |
| SCHEMBL1082129 | 0.78 | DHODH (0.67) | DHODHPARP1KDM4EHPGDSRD5A2 | |
| SCHEMBL29412049 | 0.78 | PARP1 (0.60) | DHODHPARP1 | |
| SCHEMBL6945364 | 0.78 | RAB9A (0.52) | DHODHPARP1HDAC6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936218-B1 | BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARM CO LTD (JP) | 2003-04-02 | — | — | EP | disclosed |
| US-6387938-B1 | Benzimidazole derivatives | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2002-05-14 | — | — | US | disclosed |
| EP-0936218-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 1999-08-18 | — | — | EP | disclosed |