Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ME2 | P23368 | 2/20 | 0.37 |
| ▸ | ME1 | P48163 | 2/20 | 0.37 |
| ▸ | ME3 | Q16798 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10823220 | 0.90 | CYP2C19 (0.44) | CYP2C19HIF1ATAAR1ME2ME1 | |
| SCHEMBL10823234 | 0.80 | GAA (0.31) | NPC1RAB9AGAA | |
| SCHEMBL7207085 | 0.78 | CYP2C19 (0.42) | CYP2C19HIF1ATAAR1ME2ME1 | |
| SCHEMBL10823000 | 0.78 | KMT2A (0.46) | CYP2C19HIF1AALDH1A1MAPTKMT2A | |
| SCHEMBL6918240 | 0.77 | GPR55 (0.37) | HIF1AALDH1A1HTTMAPTKMT2A | |
| SCHEMBL873147 | 0.74 | CYP2C19 (0.52) | CYP2C19HIF1ATAAR1ME2ME1 | |
| SCHEMBL29113204 | 0.74 | — | — | |
| SCHEMBL32663593 | 0.73 | CYP2C19 (0.40) | CYP2C19HIF1AALDH1A1MAPTKMT2A | |
| SCHEMBL57411 | 0.72 | CYP2C19 (0.69) | CYP2C19HIF1ATAAR1ME2ME1 | |
| SCHEMBL16964970 | 0.71 | CES1 (0.47) | HIF1AALDH1A1KMT2AHDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0089769-B1 | 9-SUBSTITUTED CARBACYCLIN ANALOGUES | THE UPJOHN COMPANY (US) | 1986-10-01 | — | — | EP | disclosed |
| US-4611005-A | BRONCHODILATORS, ASTHMA, ANTICOAGULANTS | E. R. SQUIBB & SONS, INC. (US) | 1986-09-09 | — | — | US | disclosed |
| EP-0092352-B1 | 9-SUBSTITUTED CARBACYCLINS | THE UPJOHN COMPANY (US) | 1986-07-02 | — | — | EP | disclosed |
| EP-0086611-B1 | 9-SUBSTITUTED CARBACYCLIN ANALOGUES | THE UPJOHN COMPANY (US) | 1986-05-21 | — | — | EP | disclosed |
| US-4588823-A | 9-substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1986-05-13 | — | — | US | disclosed |
| US-4585886-A | 9-Substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1986-04-29 | — | — | US | disclosed |
| US-4490555-A | 9-Substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1984-12-25 | — | — | US | disclosed |
| US-4487960-A | 9-Substituted carbacyclin analogs | THE UPJOHN COMPANY (US) | 1984-12-11 | — | — | US | disclosed |
| US-4487961-A | ANTIULCER, ANTIASTHMA, ANTICOAGULANTS | THE UPJOHN COMPANY (US) | 1984-12-11 | — | — | US | disclosed |
| EP-0092352-A1 | 9-Substituted carbacyclins | THE UPJOHN COMPANY (US) | 1983-10-26 | — | — | EP | disclosed |
| EP-0089769-A1 | 9-Substituted carbacyclin analogues | THE UPJOHN COMPANY (US) | 1983-09-28 | — | — | EP | disclosed |
| EP-0086611-A1 | 9-Substituted carbacyclin analogues | THE UPJOHN COMPANY (US) | 1983-08-24 | — | — | EP | disclosed |
| US-4028350-A | ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1977-06-07 | — | — | US | disclosed |