SCHEMBL10824218

SCHEMBL10824218

O=[N+]([O-])c1ccccc1/N=N/c1c(O)ccc2ccccc12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 7/20 0.59
▸ L3MBTL1 Q9Y468 4/20 0.59
▸ NPC1 O15118 3/20 0.59
▸ KDM4E B2RXH2 3/20 0.59
▸ MAPK1 P28482 2/20 0.59
▸ PTPN11 Q06124 2/20 0.59
▸ RAB9A P51151 1/20 0.56
▸ CYP1A2 P05177 1/20 0.54
▸ CYP2C9 P11712 1/20 0.54
▸ TSHR P16473 1/20 0.54
▸ PTPRA P18433 1/20 0.54
▸ PTPRB P23467 1/20 0.54
▸ CYP2C19 P33261 1/20 0.54
▸ HIF1A Q16665 1/20 0.54
▸ RAPGEF4 Q8WZA2 1/20 0.54
▸ HSD17B10 Q99714 1/20 0.54
▸ THRB P10828 4/20 0.54
▸ MEN1 O00255 4/20 0.51
▸ KMT2A Q03164 4/20 0.51
▸ TDP1 Q9NUW8 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10824219 1.00 MAPT (0.59) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL29356832 1.00 MAPT (0.59) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL305525 0.86 TSHR (0.57) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL29355385 0.86 TSHR (0.57) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL305524 0.86 TSHR (0.57) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL10809260 0.85 THRB (0.51) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL57955 0.85 THRB (0.67) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL5356868 0.85 THRB (0.51) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL5356875 0.85 THRB (0.51) MAPTL3MBTL1NPC1KDM4EMAPK1
SCHEMBL4223162 0.85 THRB (0.67) MAPTL3MBTL1NPC1KDM4EMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2767863-B1 SYNTHETIC RESIN LENS YAMAMOTO KOGAKU (JP) 2020-08-26 — — EP claimed
JP-61057652-A — — None — — JP disclosed
EP-2767863-B1 SYNTHETIC RESIN LENS YAMAMOTO KOGAKU (JP) 2020-08-26 — — EP disclosed
US-9362510-B2 Electroluminescent metal complexes with benzotriazoles BASF SE (DE) 2016-06-07 — — US disclosed
US-9146336-B2 Synthetic resin lens YAMAMOTO KOGAKU CO., LTD. (JP) 2015-09-29 — — US disclosed
WO-2014202216-A1 RESIN IMPREGNATED COATED ARTICLE WITH IMPROVED AESTHETIC PROPERTIES SURFACTOR GERMANY GMBH (DE) 2014-12-24 — — WO disclosed
US-20140320985-A1 SYNTHETIC RESIN LENS YAMAMOTO KOGAKU CO., LTD. (JP) 2014-10-30 — — US disclosed
EP-2767863-A1 SYNTHETIC RESIN LENS Yamamoto Kogaku Co., Ltd. (JP) 2014-08-20 — — EP disclosed
EP-2112994-B1 ELECTROLUMINESCENT METAL COMPLEXES WITH BENZOTRIAZOLES BASF SE (DE) 2011-01-26 — — EP disclosed
US-20100108994-A1 ELECTROLUMINESCENT METAL COMPLEXES WITH BENZOTRIAZOLES UDC IRELAND LIMITED (IE) 2010-05-06 — — US disclosed
WO-2008101842-A1 ELECTROLUMINESCENT METAL COMPLEXES WITH BENZOTRIAZOLES BASF SE (CH) 2008-08-28 — — WO disclosed
JP-S6157652-A NONALLERGIC AZO PIGMENT AND ITS PRODUCTION SHISEIDO CO LTD 1986-03-24 — — JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100108994-A1 ELECTROLUMINESCENT METAL COMPLEXES WITH BENZOTRIAZOLES OCIAD1, OCIAD2, OXA1L MAPT 388/4885L3MBTL1 1477/4885NPC1 4461/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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