Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | CTSB | P07858 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | KYNU | Q16719 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10705812 | 1.00 | CTSS (0.51) | CTSSCTSLCTSBMAPTL3MBTL1 | |
| SCHEMBL10706806 | 0.84 | CAPN1 (0.55) | CTSSCTSLCTSBCAPN1CTSK | |
| SCHEMBL10825080 | 0.84 | CAPN1 (0.55) | CTSSCTSLCTSBCAPN1CTSK | |
| SCHEMBL10706801 | 0.84 | CAPN1 (0.55) | CTSSCTSLCTSBCAPN1CTSK | |
| SCHEMBL3044553 | 0.78 | CTSS (0.70) | CTSSCTSLCTSBALDH1A1ALOX15 | |
| SCHEMBL13295150 | 0.78 | CTSS (0.56) | CTSSCTSLCTSBALDH1A1ALOX15 | |
| SCHEMBL22692566 | 0.78 | ALDH1A1 (0.58) | CTSSCTSLCTSBMAPTL3MBTL1 | |
| SCHEMBL21078552 | 0.78 | MAPT (0.50) | CTSSCTSLCTSBMAPTL3MBTL1 | |
| SCHEMBL23008679 | 0.77 | ALDH1A1 (0.53) | CTSSCTSLCTSBL3MBTL1ALDH1A1 | |
| SCHEMBL4395801 | 0.76 | ACE (0.51) | L3MBTL1ALOX15CTSKHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4568666-A | COLLAGENASE INHIBITORS, ANTIARTJRITIC AGENTS | G. D. SEARLE & CO. (US) | 1986-02-04 | — | — | US | disclosed |
| US-4511504-A | COLLAGENASE INHIBITORS | G.D. SEARLE & CO. (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0126974-A1 | Carboxyalkyl peptide derivatives | G.D. Searle & Co. (US) | 1984-12-05 | — | — | EP | disclosed |