Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19744864 | 1.00 | EPHX1 (0.43) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL38057 | 0.98 | EPHX1 (0.40) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL38058 | 0.98 | EPHX1 (0.40) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL38034 | 0.85 | EPHX1 (0.40) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL38032 | 0.85 | EPHX1 (0.40) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL29401399 | 0.82 | HDAC4 (0.49) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL3311032 | 0.82 | HDAC4 (0.49) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL27996141 | 0.82 | HDAC4 (0.49) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL24033741 | 0.82 | EPHX1 (0.44) | EPHX1GAAHDAC1HDAC6HDAC4 | |
| SCHEMBL24033578 | 0.82 | EPHX1 (0.44) | EPHX1GAAHDAC1HDAC6HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4603121-A | ANALGESICS | G. D. SEARLE & CO. (US) | 1986-07-29 | — | — | US | disclosed |
| US-4514332-A | Tetrapeptide adamantyl amides | G. D. SEARLE & CO. (US) | 1985-04-30 | — | — | US | disclosed |
| EP-0136720-A2 | Enkephalin analogs | G.D. Searle & Co. (US) | 1985-04-10 | — | — | EP | disclosed |
| US-4495178-A | Enkephalin analogs | G. D. SEARLE & CO. (US) | 1985-01-22 | — | — | US | disclosed |