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Sugi Predict / Compounds / Dimethylamine

Dimethylamine

Dimethylamine

SCHEMBL10825447

CNC.Cc1nc2c(s1)CN(C(=O)NC(C)C)CC2

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ DPP4 P27487 2/20 0.43
▸ DPP8 Q6V1X1 1/20 0.43
▸ DPP9 Q86TI2 1/20 0.43
▸ DPP7 Q9UHL4 1/20 0.43
▸ GRM5 P41594 16/20 0.40
▸ NPC1 O15118 1/20 0.38
▸ RAB9A P51151 1/20 0.38
▸ P2RX3 P56373 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dimethylamine SCHEMBL10825356 0.85 DPP4 (0.39) DPP4DPP8DPP9DPP7GRM5
SCHEMBL10825515 0.83 RAD52 (0.48) GRM5NPC1RAB9A
SCHEMBL16219043 0.80 DPP4 (0.49) DPP4DPP8DPP9DPP7GRM5
SCHEMBL10825441 0.78 GRM5 (0.38) GRM5NPC1RAB9AP2RX3
SCHEMBL29397882 0.78 ADRA2A (0.49) GRM5NPC1RAB9A
SCHEMBL9382117 0.78 GRM5 (0.56) DPP4DPP8DPP9DPP7GRM5
SCHEMBL10764703 0.77 GRAMD1A (0.43) NPC1RAB9A
SCHEMBL14907152 0.77 DPP4 (0.44) DPP4DPP8DPP9DPP7GRM5
SCHEMBL15889120 0.77 DPP4 (0.44) DPP4DPP8DPP9DPP7GRM5
SCHEMBL19722725 0.76 DPP4 (0.46) DPP4DPP8DPP9DPP7GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4624956-A Ulcer and gastric secretion inhibiting 4,5,6,7-tetrahydrothiazole[5,4-c]pyridine derivatives FARMITALIA CARLO ERBA (IT) 1986-11-25 — — US disclosed
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