Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 1/20 | 0.65 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.51 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.51 |
| ▸ | ANPEP | P15144 | 1/20 | 0.49 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.45 |
| ▸ | MMP2 | P08253 | 1/20 | 0.45 |
| ▸ | MMP9 | P14780 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10825548 | 1.00 | SLC1A3 (0.65) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL10825491 | 0.93 | SLC1A3 (0.62) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL10825490 | 0.93 | SLC1A3 (0.62) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL15372902 | 0.89 | SLC1A3 (0.62) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL10825360 | 0.89 | SLC1A3 (0.62) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL8390660 | 0.87 | SLC1A3 (0.78) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL29401172 | 0.87 | SLC1A3 (0.78) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| Sulfuric Acid SCHEMBL5509950 | 0.84 | SLC1A3 (0.58) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| Sulfuric Acid SCHEMBL5509948 | 0.84 | SLC1A3 (0.58) | SLC1A3SLC1A1LMNASMN1; SMN2HTT | |
| SCHEMBL2037306 | 0.84 | SLC1A3 (0.70) | SLC1A3SLC1A1LMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061186-B1 | DIPEPTIDES CONTAINING THIALYSINE AND HOMOLOGS AS ANTIHYPERTENSIVES | MERCK & CO. INC. (US) | 1986-05-21 | — | — | EP | disclosed |
| US-4512979-A | Dipeptides containing thialysine and related amino acids as antihypertensives | MERCK & CO., INC. (US) | 1985-04-23 | — | — | US | disclosed |
| EP-0061186-A1 | Dipeptides containing thialysine and homologs as antihypertensives | MERCK & CO. INC. (US) | 1982-09-29 | — | — | EP | disclosed |