Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 3/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CDK7 | P50613 | 3/20 | 0.41 |
| ▸ | CCNH | P51946 | 3/20 | 0.41 |
| ▸ | MNAT1 | P51948 | 3/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21864816 | 0.86 | SYK (0.44) | KMT2AMEN1ADORA1PIK3CAALDH1A1 | |
| SCHEMBL25449359 | 0.84 | ADORA1 (0.43) | KMT2AMEN1ADORA1PIK3CAALDH1A1 | |
| SCHEMBL30216052 | 0.84 | MAPT (0.46) | KMT2AMEN1ADORA1PIK3CABRAF | |
| SCHEMBL21864813 | 0.84 | MAPT (0.46) | KMT2AMEN1ADORA1PIK3CABRAF | |
| SCHEMBL15450886 | 0.84 | PIK3CA (0.54) | KMT2AMEN1PIK3CACCNKCCNA2 | |
| SCHEMBL21864818 | 0.76 | DGAT1 (0.41) | ADORA1PIK3CAPOLB | |
| SCHEMBL30161251 | 0.76 | DGAT1 (0.41) | ADORA1PIK3CAPOLB | |
| SCHEMBL14724666 | 0.75 | CYP1A2 (0.46) | CCNKCCNA2CDK2CDK7CCNH | |
| SCHEMBL21864812 | 0.72 | AOC3 (0.61) | — | |
| SCHEMBL25453515 | 0.72 | PIK3CA (0.34) | ADORA1PIK3CABRAFPOLBABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023025912-A1 | USE OF GCN2 INHIBITORS IN TREATING CANCER | Alesta Therapeutics BV (NL) | 2023-03-02 | — | — | WO | disclosed |
| EP-0204529-A2 | Anti-cancer quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 1986-12-10 | — | — | EP | disclosed |
| US-4564616-A | Anti-cancer quinazoline derivatives | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1986-01-14 | — | — | US | disclosed |
| EP-0031237-B1 | QUINAZOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANTI-CANCER AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-10-17 | — | — | EP | disclosed |
| US-4447608-A | ANTITUMOR AGENTS | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1984-05-08 | — | — | US | disclosed |
| EP-0031237-A1 | Quinazoline derivatives, processes for their preparation, compositions containing them and their use as anti-cancer agents | NATIONAL RESEARCH DEVELOPMENT CORPORATION (GB) | 1981-07-01 | — | — | EP | disclosed |